Inositol Hexaphosphate IP6 has, in research sinceinhibited the onset and progression of cancers in animals, but supportive research in humans is lacking. All research suggesting beneficial effects from taking IP6 involve animals and not humans. It is not known whether IP6 would be useful for the treatment of human disease or, if so, what would be the optimal amount.
IP6 is associated with dietary fiber and thus is naturally present in a wide variety of plant foods, especially wheat bran, whole grains and legumes. The average dietary intake ranges from Inositol is a B-vitamin and its derivative, IP6 is a natural component of some grain and legumes, particularly soybeans.
IP6 is available without prescription in most health food stores. Research has shown that IP6 can help prevent kidney stone formation, complications of diabetes i. It is calcium binding, thus preventing formation of the most common type of kidney stone calcium oxalate.
Its antioxidant and iron building properties inhibit the progression of lung fibrosis in asbestosis. Although used primarily by the community of Alternative Medical Doctors and some open-minded orthodox oncologists medical cancer doctors because it suppresses almost all types of cancer, it has some other fantastic benefits for longevity.
Independently, IP6 regulates the oxygen capacity of our red blood cells ; it reduces both cholesterol and triglyceridesas well as preventing heart damage during a heart attack. In diabetes cases, it not only improves insulin sensitivity, but also decreases complications. In preliminary studies, IP6 prevents depression and may work adjunctively in schizophrenia. The all-important function of enhancing of our immune system, by increasing the activity of our natural killer NK cells, may make IP6 the 'aspirin' of the future.
When IP6 is recommended, the dose is gm daily, which should be taken on an empty stomach to avoid interaction with dietary proteins. Consider taking supplemental inositol with IP6 because additional unbound inositol multiplies its therapeutic activity.
Specifically, the normal recommend dosage is gm per day, taken between meals twice a day to avoid its interaction with protein in the diet. For individuals with a high risk of cancer, cardiovascular disease, kidney stonesetc. Finally, to help existing cancer, gm per day.
IP6 is "as safe as water". However, caution is advised when using IP6 supplementally for an extended period. Phytate in foods reduces mineral absorption, especially iron.
Supplemental phytate IP6 will further contribute to this potential problem and thus additional mineral supplementation may be required. IP6 — found in brown rice and corn and extracted as a commercial product — promotes NK function and thus helps balance a TH2 dominant immune system. IP6 - Inositol Hexaphosphate.
Studies performed on breast cancer cells have demonstrated increased efficacy of two commonly used breast cancer drugs doxorubicin and tamoxifen when combined with IP6.
The best albeit very small clinical study I found looked at the use of IP6 and inositol versus placebo in breast cancer patients receiving 6-months of chemotherapy. The authors stated that this dose was likely too low to see any anticancer activity as the effective dose levels used in animal studies extrapolated to humans would be higher. They wrote:. IP6 has anti-platelet activity, so it may increase the risk of bleeding when used with other anticoagulants or anti-platelet drugs.
As always, discuss your use of any supplement with your physicians before taking them. In the absence of any high quality, large-scale studies the data is not strong enough at this time to say definitively whether IP6 is beneficial for having any anticancer activity in humans. I remain cautiously optimistic on the potential anticancer effects of IP6. We need to await larger confirmatory studies to know if IP6 has these beneficial effects as well. All that being said, since the side effect profile of IP6 is very low see precautions abovethere is no major downside for those of you who want to give it a try.
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About Brian Lawenda M. Facebook Twitter YouTube. Search site. Even though our dosage was low, its efficacy to diminish the side effects of chemotherapy was significant. Recent phase I study of inositol for lung cancer chemoprevention showed that in a daily dose of 18 g for 3 months, inositol was safe and well tolerated [ ref ].
Enroll Now. We will never share your email address and you can easily opt-out at any time.What is IP6 Health? It is made from rice bran. There is debate as to whether IP6 should also be considered our newest vitamin, but at this time it has not been officially designated as a vitamin. Is IP6 Health Safe? This natural antioxidant is a very safe food based supplement.
However, there are two main instances when one should exercise caution and discontinue or lower the dosage.Renew Your Health with IP6 (and Inositol)
The first is with pregnancy, as it has not been tested specifically with expectant mothers. The second is with patients who are on blood thinners or are expecting to have an operation.
This supplement has an inhibitory affect on our platelets, which under normal circumstances is considered a benefit.
Please see the IP6 Health Safety page for more info. Is IP6 fiber? No, it exists in both plant and animal cells, but the confusion arises because the highest concentrations are found in fiber, especially insoluble fiber. In fact IP6 is found in many places, including the soil and in all of our own cells.
What are natural sources of IP6? To get levels high enough to influence our health we rely on plant sources, legumes and grains predominantly. Corn happens to have the highest levels. However as a supplement, IP6 is often extracted from the bran of rice, which is removed when brown rice is polished and converted into white rice.
The reality is that by eating white rice one is missing out on the health benefits of IP6. The amount of IP6 in common food sources: Barley: 1. How much calcium and magnesium are there in IP6 Health? For every milligrams of IP6 Health there are approximately milligrams of calcium and 47 milligrams of magnesium. Since the IP6 molecule is a natural chelating agent, do I need to worry about losing calcium?
No, if anything IP6 Health provides far more calcium and magnesium than it can remove. When we consume IP6 it has calcium and magnesium bound to it. Even at conservative estimates, the supplement would supply at least 33 times more calcium and magnesium than it can remove, via its natural chelating effect. In other words, with IP6 we are taking in at least 33 times more calcium than we can lose in the urine.
This certainly would not be the case if IP6 led to lost or depleted calcium levels. What is inositol? Inositol is as a B vitamin, but oddly enough a RDA has never been established. Is IP6 a B vitamin?Make IP6 Gold a part of your daily program for prevention and wellness. One of the most exciting nutritional products to be introduced in years is the combination of IP6 Inositol Hexaphosphate and Inositol. This combination of naturally occurring compounds produced from rice bran has demonstrated impressive immune enhancing effects in scientific research.
Research from around the world continues to expand and validate findings. IP6 Inositol Hexaphosphate is a naturally occurring compound found primarily in grains and legumes.
The health benefits of a diet high in fiber seem to be due to the high levels of IP6 in the fiber. Purified IP6 offers several advantages over dietary IP Its rapid absorption compared to dietary IP6 ensures much superior bio availability. This in turn exerts significant benefits to the support of the immune system. Several researchers theorized that when Inositol was properly combined with IP6, it formed two molecules of IP3 in the body through dephosphorylation.
Although IP6 gets all the attention, it is really the IP3 that is doing all the work. IP3 plays an important role in cells by helping them grow, mature, replicate and communicate with other cells. Cells that are low in IP3 can become out of control, dividing uncontrollably. Studies confirm that the combination of IP6 with Inositol yields much greater effects than IP6 alone. Recognized as a potent antioxidant, IP6 acts to neutralize the damaging effects of free radicals on body cells and has been shown to enhance the immune system and support healthy cellular activity.
Millions of dollars are currently being spent in research related to DNA profiling and alteration. Here we see a very natural compound plays an important role in this complex mechanism. IP6 and Inositol has undergone extensive animal and human studies. No negative side-effects have been found, either when IP6 and Inositol is used on its own or in combination with other dietary supplements or conventional allopathic treatments.
For those with known immune system difficulties the recommended usage is 8 capsules or 1 scoop of bulk powder, twice daily. To achieve maximum benefit IP-6 with Inositol is best taken on an empty stomach. IP6 with Inositol is found naturally within every body cell. In experimental studies, no adverse side effects have been noted even with prolonged use at high doses.
There are no known drug-nutrient interactions. Extensive research studies indicate that IP6 and Inositol are a safe and natural combination. What is IP6? IP6 Gold as an Antioxidant and Immune Booster Recognized as a potent antioxidant, IP6 acts to neutralize the damaging effects of free radicals on body cells and has been shown to enhance the immune system and support healthy cellular activity.Inositol hexaphosphate, sometimes called vitamin B-8 or simply IP6, is a chemical found in a number of foods, including beans, grains, nuts and seeds.
IP6 is also sold over-the-counter as a dietary supplement to treat depression and as an antioxidant and cancer prevention agent. Like any substance, IP6 can have side effects. IP6 appears to have few actual side effects, although some effects are reported more often than others. Stomach disturbances such as nausea, gas, flatulence or stomach upset may occur.
Other common side effects include headache, dizziness and fatigue. IP6 could increase the risk of bleeding in people taking blood-thinning medication such as aspirin or anticoagulants such as warfarin. If you take medications that prevent blood clotting, talk with your doctor before taking IP6. Decreased mineral absorption could result in mineral and vitamin deficiencies. This concern has been raised mostly in cases of IP6 given to infants, the American Cancer Society states.
Although IP6 is sometimes used to treat depression and has been tried as a supplement to treat bipolar disorder along with psychiatric conditions such as obsessive-compulsive disorder, several cases of worsening bipolar disorder or a new onset of hypomania have occurred in people taking IP6. Perkins also has extensive experience working in home health with medically fragile pediatric patients.
Monitor the health of your community here. More Articles. Diseases and Injuries. Written by Sharon Perkins. If you are experiencing serious medical symptoms, seek emergency treatment immediately.
D, et al. Joseph Levine, M. About the Author.At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider.
Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Inositol is a simple carbohydrate that belongs to a class of compounds called polyols. It has a six-membered carbon ring with six chemical groups called hydroxyl groups attached to it.
Inositol with six phosphate groups attached is called inositol hexaphosphate or phytic acid or IP-6 1 2. Neither compound is an essential dietary nutrient, although both compounds have been studied for their roles and possible applications in human health.
IP6 - Inositol Hexaphosphate
IP-6 is often found in the form of an insoluble salt, calcium phytate. Humans and other animals, such as pigs, with a similar digestive system can only digest phytate to a limited extent, so they are unable to retrieve most of the phosphate bound to the phytate. Ruminant animals, such as cows, however, can digest phytate and retrieve phosphate from it; phytate in fodder can benefit these animals and cattle ranchers by providing a rich source of phosphate in the cows' diet. According to the American Cancer Society, scientists have found IP-6 can sometimes slow the growth of tumor cells in petri dishes 2 2.
There is also evidence to suggest it may help prevent tumors from forming in specific organs in lab animals. At present, however, researchers do not know if it exhibits similar effects in humans. Moreover, high levels of dietary phytate can potentially bind and lock up certain minerals like calcium and zinc, preventing the body from absorbing them.
As noted in a review in the Cochrane Library, there is some reason to think inositol supplementation might be helpful in the treatment of depression, although the evidence is unclear. A study in the New England Journal of Medicine found evidence that d-chiro inositol, a specific form of the compound, might be helpful in the treatment of polycystic ovary syndrome 6. Further research would be needed to confirm inositol's effectiveness in the treatment of either condition.
Based in San Diego, John Brennan has been writing about science and the environment since Monitor the health of your community here. More Articles.
NCBI PubChem: Phytic Acid The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider.
IP6 as a calcium chelator?
Diseases and Injuries. Written by John Brennan. If you are experiencing serious medical symptoms, seek emergency treatment immediately.Buy IP-6 supplement high quality Buy IP-6 supplement or get a free newsletter on alternative healing methods. Suggested Use, dosage: Take 1 or two IP6 capsules daily or as recommended by your health care professional.
What is the right dosage for cancer treatment? There are many types and stages of cancer and it is not possible to provide specific dosage suggestions that would apply to everyone. Cancer treatment or prevention Inositol hexaphosphate is a component of certain dietary fibers, particularly most cereal grains, legumes, and seeds high in oil. Many researchers believe that some of fiber's health benefits may be due to the antioxidant, immune enhancing, and cardiovascular supporting activities of IP In-vitro and animal research has shown IP-6 to have significant protective and growth regulating effects on various cells and tissues including those of the colon, breast, and prostate.
IP-6 has been reported to have in vivo and in vitro anti- cancer activity against numerous tumors, such as colon cancerprostate cancer, breast cancerliver cancerchronic myeloid leukemiapancreatic cancer, and rhabdomyosarcomas. Significant human trials are lacking and hence we do not currently know for certain whether taking IP-6 supplements are helpful in cancer prevention or therapy, but the early data look promising.
AbulKalam M. Sincehe has been researching the processes of cancer formation, prevention and treatment. AbulKalam Shamsuddin has written a book discussing how diets high in bran or Inositol hexaphosphate inhibit cancer development in laboratory animals. Studies show IP6 can help fight bacterial and fungal infections.
The substance is found in the germ or bran portions of whole grains; the highest concentration is found in whole-kernel corn. IP6 can be added to one's diet by eating whole-grain foods. Bladder cancer Curr Urol. In vitro regulation of cell growth and angiogenesis by inositol hexaphosphate in bladder cancer. In vitro treatment of bladder cancer with the common dietary polyphosphorylated carbohydrate IP6 significantly decreased cellular growth by anti-angiogenic mechanisms.
Breast cancer IP6 inhibits the growth of breast cancer cells; but it also acts synergistically with adriamycin or tamoxifen, being particularly effective against estrogen responsive alpha-negative cells and adriamycin-resistant cell lines. Patients with invasive ductal breast cancer where polychemotherapy was indicated were monitored. Fourteen patients in the same stage of ductal invasive breast cancer were involved in the study, divided in two randomized groups.
Red blood cell counts and tumor markers were unaltered in both groups. J Exp Clin Cancer Res.
What Is IP6 (Inositol Hexaphosphate)?
Colon cancer Int J Mol Sci. Pro-apoptotic effect of rice bran inositol hexaphosphate IP6 on HT colorectal cancer cells.
IP6, or phytic acid is a natural dietary ingredient and has been described as a "natural cancer fighter", being an essential component of nutritional diets.